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KMID : 0377519810060030309
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Chung-Ang Journal of Medicine
1981 Volume.6 No. 3 p.309 ~ p.316
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Effects of Aconiti Tuber Butanol fraction on Electrical and Bechanical Properties of Cardiac Muscle
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Chung Hak-Ki
Cho Sung-Il
Uhm Dae-Yong
Rhee Sang-Don
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Abstract
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In order to investigate the action mechanism of Aconiti tuber butanol fraction (ABF) on the isometric contraction of cardiac muscle cells, transmembrane potential and action potential which was picked up by 3 M KCI glass microelectrode were recorded at the same time in rabbit papillary muscle preparations from right ventricles. The isometric contraction and action potential were recorded from the papillary muscles superfused in the control Tyrode solution and ABF Tyrode solution in which the preparations were kept beating (lHz) for about 30 minutes to get stable data. The resting membrane potential, amplitude of action potential, the amplitude of overshoot potential, time to repolarize 60%, 90% of the amplitude of action potential and the first derivatives of potential variations in plateau and repolarization were analyzed from recorded transmembrane action potential control Tyrode solution and ABF (5×10^-4~2×10^-3gm/ml)-Tyrode solution in wihth howesd about in 150% of positive isotropic effect compared with those controls. The following results were obtained to compare those parameters in the controls and in the ABF-Tyrode groups: 1. ABF shortened the time-to-peak tension from the value of 155 ms in the controls to 138 ms in. the experimental groups (0.05
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